Immunogen
Synthesized peptide derived from human SMC6 AA range: 719-769
Specificity
This antibody detects endogenous levels of human SMC6
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Protein name
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Human protein sequence Database
Q96SB8
Mouse protein sequence database
Q924W5
Rat protein sequence database
Cellular localization
Nucleus . Nucleus speckle . Chromosome . Nucleus, PML body . Chromosome, telomere . Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). Localizes in interchromatin granule clusters (PubMed:11408570). .
Tissue expression
Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570).
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