Molecular weight (DA)
46kD
Immunogen
Synthesized peptide derived from human PDK4 AA range: 34-84
Specificity
This antibody detects endogenous levels of PDK4 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% sodium azide.
Dilution rate
IHC-p1:50-200 ,WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Pyruvate dehydrogenase kinase isoform4 (PDK4) is also named as PDHK4 and belongs to the PDK/BCKDK protein kinase family. It is upregulated by starvation in many tissues of the body during starvation. This causes inactivation of the pyruvate dehydrogenase complex which blocks pyruvate oxidation and conserves lactate and alanine for gluconeogenesis.
Other name
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)
Fields
>>Diabetic cardiomyopathy
Human protein sequence Database
Q16654
Mouse protein sequence database
O70571
Rat protein sequence database
O54937
Cellular localization
Mitochondrion matrix.
Tissue expression
Ubiquitous; highest levels of expression in heart and skeletal muscle.
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