Molecular weight (DA)
23kD
Immunogen
Synthesized phosho peptide around human MOB1 (Thr12)
Specificity
This antibody detects endogenous levels of Human Mouse Rat MOB1 (phospho-Thr12)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
Function
function:Stimulates the kinase activity of STK38 and STK38L.,PTM:Phosphorylated.,similarity:Belongs to the MOB1/phocein family.,subunit:Binds STK38 and STK38L.,
Protein name
MOB1 (Thr12)
Other name
MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B)
Fields
>>Hippo signaling pathway;>>Hippo signaling pathway - multiple species
Human protein sequence Database
Q9H8S9
Mouse protein sequence database
Q921Y0
Rat protein sequence database
Q3T1J9
Cellular localization
cytosol,extracellular exosome,
Tissue expression
Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.
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