Molecular weight (DA)
45kD
Immunogen
Synthesized phosho peptide around human RCC1 (Ser11)
Specificity
This antibody detects endogenous levels of Human RCC1 (phospho-Ser11)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
disease:Patients with Raynaud disease produce antibodies that bind to RCC1.,function:Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.,similarity:Contains 7 RCC1 repeats.,subcellular location:Becomes dispersed throughout the cytoplasm during mitosis.,
Protein name
RCC1 (Ser11)
Other name
Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)
Human protein sequence Database
P18754
Mouse protein sequence database
Q8VE37
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Cytoplasm . Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449). .
Tissue expression
Brain,Breast,Epithelium,Eye,Muscle,Testis,
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