Immunogen
Synthesized peptide derived from human USP28 (Phospho-Ser714)
Specificity
This antibody detects endogenous levels of USP28 (Phospho-Ser714) at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.182% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016],
Function
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,
Protein name
USP28 (Phospho-Ser714)
Other name
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)
Human protein sequence Database
Q96RU2
Mouse protein sequence database
Q5I043
Rat protein sequence database
D3ZJ96
Cellular localization
Nucleus, nucleoplasm .
Tissue expression
Brain,Eye,
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