Immunogen
Synthesized peptide derived from human MAZ (Phospho-Thr72)
Specificity
This antibody detects endogenous levels of MAZ (Phospho-Thr72) at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.197% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the c-myc promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors.,similarity:Contains 6 C2H2-type zinc fingers.,subcellular location:In brains of Alzheimer disease patients, present in a plaque-like structures.,subunit:Interacts with BPTF.,tissue specificity:Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).,
Protein name
MAZ (Phospho-Thr72)
Other name
Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801)
Human protein sequence Database
P56270
Mouse protein sequence database
P56671
Rat protein sequence database
Cellular localization
Nucleus . In brains of Alzheimer disease patients, present in a plaque-like structures.
Tissue expression
Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). ; [Isoform 1]: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle and weakly expressed in the kidney (PubMed:1502157). Expressed in the joint synovium (PubMed:19583771).
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