Molecular weight (DA)
50kD
Immunogen
Synthesized peptide derived from human EIF5 (Phospho-Ser389+Ser390)
Specificity
This antibody detects endogenous levels of EIF5 (Phospho-Ser389+Ser390) at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.200% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010],
Function
function:Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).,similarity:Belongs to the eIF-2-beta/eIF-5 family.,similarity:Contains 1 W2 domain.,
Protein name
EIF5 (Phospho-Ser389+Ser390)
Other name
Eukaryotic translation initiation factor 5 (eIF-5)
Human protein sequence Database
P55010
Mouse protein sequence database
P59325
Rat protein sequence database
Q07205
Cellular localization
nucleus,cytoplasm,cytosol,plasma membrane,cell-cell adherens junction,
Tissue expression
Brain,Epithelium,Lymph,Pooled,Uterus,
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