Immunogen
Synthesized peptide derived from human R-Ras (Phospho-Tyr66)
Specificity
This antibody detects endogenous levels of R-Ras (Phospho-Tyr66) at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.220% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015],
Function
function:Regulates the organization of the actin cytoskeleton.,similarity:Belongs to the small GTPase superfamily. Ras family.,subcellular location:Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).,subunit:Interacts with PLCE1.,
Protein name
R-Ras (Phospho-Tyr66)
Other name
Ras-related protein R-Ras (p23)
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>cAMP signaling pathway;>>Phospholipase D signaling pathway;>>Mitophagy - animal;>>Autophagy - animal;>>Cellular senescence;>>Axon guidance;>>Apelin signaling pathway;>>C-type lectin receptor signaling pathway;>>Regulation of actin cytoskeleton;>>Salmonella infection;>>Proteoglycans in cancer
Human protein sequence Database
P10301
Mouse protein sequence database
P10833
Rat protein sequence database
D3Z8L7
Cellular localization
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
Tissue expression
Adipocyte,Brain,Uterus,
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