Molecular weight (DA)
17kD
Immunogen
Synthetic Peptide of GABARAP AA range: 26-75
Specificity
GABARAP Polyclonal Antibody detects endogenous levels of GABARAP
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MAP1 LC3 family.,subunit:Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1.,tissue specificity:Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.,
Function
function:Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MAP1 LC3 family.,subunit:Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1.,tissue specificity:Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.,
Gene Name
GABARAPL2 FLC3A GEF2
Other name
GABA(A) receptor-associated protein-like 2
Fields
>>FoxO signaling pathway;>>Autophagy - other;>>Mitophagy - animal;>>Autophagy - animal;>>NOD-like receptor signaling pathway;>>GABAergic synapse
Human protein sequence Database
P60520
Mouse protein sequence database
P60521
Rat protein sequence database
P60522
Cellular localization
Cytoplasmic vesicle, autophagosome . Endoplasmic reticulum membrane . Golgi apparatus .
Tissue expression
Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.
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