Molecular weight (DA)
140kD
Immunogen
Synthetic peptide from human protein at AA range: 930-1000
Specificity
The antibody detects endogenous ULK2 protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
unc-51 like autophagy activating kinase 2(ULK2) Homo sapiens This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.,similarity:Contains 1 protein kinase domain.,
Protein name
unc-51-like kinase 2 (C. elegans)
Fields
>>Autophagy - other;>>Autophagy - animal;>>mTOR signaling pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
Q8IYT8
Mouse protein sequence database
Q9QY01
Rat protein sequence database
Cellular localization
Cytoplasmic vesicle membrane ; Peripheral membrane protein . Localizes to pre-autophagosomal membrane.
Tissue expression
Brain,Testis,
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