Molecular weight (DA)
45kD
Immunogen
Synthetic peptide from human protein at AA range: 301-350
Specificity
The antibody detects endogenous RCC1 protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000,IHC-p 1:50-200 ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
disease:Patients with Raynaud disease produce antibodies that bind to RCC1.,function:Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.,similarity:Contains 7 RCC1 repeats.,subcellular location:Becomes dispersed throughout the cytoplasm during mitosis.,
Function
disease:Patients with Raynaud disease produce antibodies that bind to RCC1.,function:Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.,similarity:Contains 7 RCC1 repeats.,subcellular location:Becomes dispersed throughout the cytoplasm during mitosis.,
Protein name
regulator of chromosome condensation 1; SNHG3-RCC1 readthrough transcript
Human protein sequence Database
P18754
Mouse protein sequence database
Q8VE37
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Cytoplasm . Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449). .
Tissue expression
Brain,Breast,Epithelium,Eye,Muscle,Testis,
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