Immunogen
Synthetic peptide from human protein at AA range: 50-90
Specificity
The antibody detects endogenous DDT
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008],
Function
catalytic activity:D-dopachrome = 5,6-dihydroxyindole + CO(2).,function:Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).,similarity:Belongs to the MIF family.,subunit:Homotrimer.,
Protein name
D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) (Phenylpyruvate tautomerase II)
Other name
D-dopachrome decarboxylase (EC 4.1.1.84;D-dopachrome tautomerase;Phenylpyruvate tautomerase II)
Human protein sequence Database
P30046
Mouse protein sequence database
O35215
Rat protein sequence database
P80254
Cellular localization
Cytoplasm .
Tissue expression
Highly expressed in the liver and at lower levels in the heart, lung and pancreas.
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