Immunogen
Synthetic peptide from human protein at AA range: 221-270
Specificity
The antibody detects endogenous CD158k
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2(KIR3DL2) Homo sapiens Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the
Function
function:Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,
Gene Name
KIR3DL2 CD158K NKAT4
Protein name
Killer cell immunoglobulin-like receptor 3DL2 (CD158 antigen-like family member K) (MHC class I NK cell receptor) (Natural killer-associated transcript 4) (NKAT-4) (p70 natural killer cell receptor cl
Other name
Killer cell immunoglobulin-like receptor 3DL2 (CD158 antigen-like family member K;MHC class I NK cell receptor;Natural killer-associated transcript 4;NKAT-4;p70 natural killer cell receptor clone CL-5;p70 NK receptor CL-5;CD antigen CD158k)
Fields
>>Antigen processing and presentation;>>Natural killer cell mediated cytotoxicity;>>Graft-versus-host disease
Human protein sequence Database
P43630
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane; Single-pass type I membrane protein.
Tissue expression
Expressed in astrocytes.
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