Immunogen
Synthetic peptide from human protein at AA range: 191-240
Specificity
The antibody detects endogenous Napsin A
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016],
Function
function:May be involved in processing of pneumocyte surfactant precursors.,similarity:Belongs to the peptidase A1 family.,tissue specificity:Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.,
Gene Name
NAPSA NAP1 NAPA
Protein name
Napsin-A (EC 3.4.23.-) (Aspartyl protease 4) (ASP4) (Asp 4) (Napsin-1) (TA01/TA02)
Other name
Napsin-A (EC 3.4.23.-;Aspartyl protease 4;ASP4;Asp 4;Napsin-1;TA01/TA02)
Human protein sequence Database
O96009
Mouse protein sequence database
O09043
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.
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