Immunogen
Synthetic peptide from human protein at AA range: 141-190
Specificity
The antibody detects endogenous CD242
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
Function
function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.,online information:Blood group antigen gene mutation database,polymorphism:Responsible for the Landsteiner-Wiener blood group system. The molecular basis of the LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and Arg-100 to LW(B).,PTM:N- and O-glycosylated.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Erythrocytes.,
Protein name
Intercellular adhesion molecule 4 (ICAM-4) (Landsteiner-Wiener blood group glycoprotein) (LW blood group protein) (CD antigen CD242)
Other name
Intercellular adhesion molecule 4 (ICAM-4;Landsteiner-Wiener blood group glycoprotein;LW blood group protein;CD antigen CD242)
Human protein sequence Database
Q14773
Mouse protein sequence database
Q9ERM2
Rat protein sequence database
Cellular localization
[Isoform Long]: Cell membrane; Single-pass type I membrane protein.; [Isoform Short]: Secreted .; Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Erythrocytes.
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