Molecular weight (DA)
63kD
Immunogen
Synthesized peptide derived from human NUT. at AA range: 1082-1131
Specificity
This antibody detects endogenous levels of NUT
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
disease:A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein.,disease:A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein.,PTM:Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.,similarity:Belongs to the FAM22 family.,subcellular location:Shuttles between nucleus and cytoplasm.,tissue specificity:Specifically expressed in testis.,
Function
disease:A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein.,disease:A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein.,PTM:Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.,similarity:Belongs to the FAM22 family.,subcellular location:Shuttles between nucleus and cytoplasm.,tissue specificity:Specifically expressed in testis.,
Other name
Protein NUT (Nuclear protein in testis)
Human protein sequence Database
Q86Y26
Mouse protein sequence database
Q8BHP2
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Shuttles between nucleus and cytoplasm. .
Tissue expression
Specifically expressed in testis.
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