Molecular weight (DA)
110kD
Immunogen
Synthesized peptide derived from human FIG4. at AA range: 341-390
Specificity
This antibody detects endogenous levels of FIG4
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008],
Function
phospholipid metabolic process, glycerophospholipid metabolic process, vacuole organization, behavior, locomotory behavior, cell death, death, organophosphate metabolic process, neuron differentiation, phosphoinositide metabolic process, pigmentation, glycerolipid metabolic process, neuron development,
Gene Name
FIG4 KIAA0274 SAC3
Other name
Polyphosphoinositide phosphatase (EC 3.1.3.-) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3)
Fields
>>Inositol phosphate metabolism;>>Metabolic pathways;>>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
Q92562
Mouse protein sequence database
Q91WF7
Rat protein sequence database
Cellular localization
Endosome membrane . Localization requires VAC14 and PIKFYVE. .
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