Molecular weight (DA)
56kD
Immunogen
Synthesized peptide derived from human GCM2. at AA range: 21-70
Specificity
GCM2 Polyclonal Antibody detects endogenous levels of GCM2
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008],
Function
function:Probable transcriptional regulator.,similarity:Contains 1 GCM DNA-binding domain.,
Other name
Chorion-specific transcription factor GCMb (hGCMb) (GCM motif protein 2) (Glial cells missing homolog 2)
Fields
>>Parathyroid hormone synthesis, secretion and action
Human protein sequence Database
O75603
Mouse protein sequence database
O09102
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Brain,Fetal brain,
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