Molecular weight (DA)
48kD
Immunogen
Synthesized peptide derived from human KIR3.2
Specificity
This antibody detects endogenous levels of human KIR3.2
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015],
Function
function:This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.,tissue specificity:Most abundant in cerebellum, and to a lesser degree in islet
Gene Name
KCNJ6 GIRK2 KATP2 KCNJ7
Other name
G protein-activated inward rectifier potassium channel 2 (GIRK-2;BIR1;Inward rectifier K(+) channel Kir3.2;KATP-2;Potassium channel, inwardly rectifying subfamily J member 6)
Fields
>>Circadian entrainment;>>Retrograde endocannabinoid signaling;>>Cholinergic synapse;>>Serotonergic synapse;>>GABAergic synapse;>>Dopaminergic synapse;>>Estrogen signaling pathway;>>Oxytocin signaling pathway;>>GnRH secretion;>>Morphine addiction
Human protein sequence Database
P48051
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.
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