Immunogen
Synthesized peptide derived from human SEC61B AA range: 30-110
Specificity
This antibody detects endogenous levels of human SEC61B
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA(peptide)1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008],
Function
function:Necessary for protein translocation in the endoplasmic reticulum.,similarity:Belongs to the SEC61-beta family.,subunit:Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62.,
Other name
Protein transport protein Sec61 subunit beta
Fields
>>Protein export;>>Protein processing in endoplasmic reticulum;>>Phagosome;>>Vibrio cholerae infection
Human protein sequence Database
P60468
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass membrane protein .
Tissue expression
Brain,Embryonic kidney,Epithelium,Stomach mucosa,
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