Immunogen
Synthesized peptide derived from human MYCNOS AA range: 2-52
Specificity
This antibody detects endogenous levels of human MYCNOS
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016],
Function
developmental stage:Expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels.,function:May have a functional role during normal fetal development.,tissue specificity:Expressed in the fetal brain, lung, liver and kidney at varying low levels.,
Gene Name
MYCNOS CYMN NCYM
Other name
N-cym protein (N-myc opposite strand)
Human protein sequence Database
P40205
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus .
Tissue expression
Expressed in the neuronal cells of the cerebrum and cerebellum, spermatocytes of the testis, pancreatic cells and also the heart. Expressed in both primary and metastatic neuroblastomas and in thyroid tumors (at protein level). Expression is associated with poor prognosis in neuroblastoma. Expressed in the fetal brain, lung, liver and kidney at varying low levels.
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