Immunogen
Synthesized peptide derived from human Beta-defensin 4A AA range: 1-50
Specificity
This antibody detects endogenous levels of human Beta-defensin 4A
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA(peptide)1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008],
Function
function:Has antibacterial activity .,induction:By inflammation.,similarity:Belongs to the beta-defensin family. LAP/TAP subfamily.,tissue specificity:Expressed in the skin and respiratory tract.,
Gene Name
DEFB4A DEFB102 DEFB2 DEFB4; DEFB4B
Protein name
Beta-defensin 4A
Abbreviation
Beta-defensin 4A
Other name
Beta-defensin 4A (Beta-defensin 2;BD-2;hBD-2;Defensin, beta 2;Skin-antimicrobial peptide 1;SAP1)
Fields
>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Staphylococcus aureus infection
Human protein sequence Database
O15263
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed in the skin and respiratory tract.
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