Immunogen
Synthesized peptide derived from human Beta-defensin 1 AA range: 1-50
Specificity
This antibody detects endogenous levels of human Beta-defensin 1
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA(peptide)1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008],
Function
function:Has bactericidal activity.,mass spectrometry: PubMed:7628632,similarity:Belongs to the beta-defensin family.,tissue specificity:Plasma.,
Protein name
Beta-defensin 1
Abbreviation
Beta-defensin 1
Other name
Beta-defensin 1 (BD-1;hBD-1;Defensin, beta 1)
Fields
>>ABC transporters;>>Staphylococcus aureus infection
Human protein sequence Database
P60022
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted . Membrane . Associates with tumor cell membrane-derived microvesicles (PubMed:23938203). .
Tissue expression
Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
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