Immunogen
Synthesized peptide derived from human ITF Polyclonal AA range: 1-50
Specificity
This antibody detects endogenous levels of human ITF Polyclonal
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA(peptide)1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008],
Function
function:Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).,similarity:Contains 1 P-type (trefoil) domain.,subunit:Monomer. Homodimer; disulfide-linked.,tissue specificity:Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus.,
Protein name
ITF Polyclonal
Other name
Trefoil factor 3 (Intestinal trefoil factor;hITF;Polypeptide P1.B;hP1.B)
Human protein sequence Database
Q07654
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted, extracellular space, extracellular matrix . Cytoplasm .
Tissue expression
Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level).
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