Immunogen
Synthesized peptide derived from human Glutaredoxin-1 AA range: 8-58
Specificity
This antibody detects endogenous levels of human Glutaredoxin-1
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011],
Function
function:Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.,similarity:Belongs to the glutaredoxin family.,similarity:Contains 1 glutaredoxin domain.,
Protein name
Glutaredoxin-1
Abbreviation
Glutaredoxin-1
Other name
Glutaredoxin-1 (Thioltransferase-1;TTase-1)
Human protein sequence Database
P35754
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm.
Tissue expression
Blood,Brain,Lens,Liver,Skin,Spleen,Urinary bladder,
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