Immunogen
Synthesized peptide derived from human REN3A AA range: 190-240
Specificity
This antibody detects endogenous levels of REN3A at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Part of a multiprotein post-splicing mRNP complex involved in both mRNA nuclear export and mRNA surveillance. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Binds spliced mRNA upstream of exon-exon junctions.,similarity:Belongs to the RENT3 family.,subcellular location:Shuttling between the nucleus and the cytoplasm.,subunit:Found in a mRNP complex with RENT1, RENT2, RENT3A and RENT3B. Found in a mRNP complex with SMG1, RENT3A, RENT3B, RBM8A, THOC4 and NXF1. Found in a post-splicing complex with NXF1, RBM8A, RENT1, RENT2, RENT3A, RENT3B and RNPS1. Interacts with RENT2.,tissue specificity:Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord.,
Gene Name
UPF3A RENT3A UPF3
Fields
>>Nucleocytoplasmic transport;>>mRNA surveillance pathway
Human protein sequence Database
Q9H1J1
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Shuttling between the nucleus and the cytoplasm. .
Tissue expression
Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车