Immunogen
Synthesized peptide derived from human LRWD1 AA range: 395-445
Specificity
This antibody detects endogenous levels of LRWD1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
Function
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 LRR (leucine-rich) repeats.,similarity:Contains 5 WD repeats.,
Human protein sequence Database
Q9UFC0
Mouse protein sequence database
Q8BUI3
Rat protein sequence database
Cellular localization
Nucleus . Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.
Tissue expression
Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS).
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