Immunogen
Synthesized peptide derived from human FXYD3 AA range: 15-65
Specificity
This antibody detects endogenous levels of FXYD3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008],
Function
function:Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.,miscellaneous:Marker of a cell type preferentially transformed by neu or ras oncoprotein.,similarity:Belongs to the FXYD family.,tissue specificity:Expressed in a subset of human breast tumors.,
Gene Name
FXYD3 MAT8 PLML
Human protein sequence Database
Q14802
Mouse protein sequence database
Q61835
Rat protein sequence database
P59645
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Isoform 1: Expressed mainly in differentiated cells (at protein level). Isoform 2: Expressed mainly in undifferentiated cells (at protein level).
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