Immunogen
Synthesized peptide derived from human CCHCR AA range: 180-230
Specificity
This antibody detects endogenous levels of CCHCR at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:May be a regulator of keratinocyte proliferation or differentiation.,polymorphism:HCR*WWCC is associated with susceptibility to psoriasis. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is a multifactorial disease characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by hyperproliferative keratinocytes and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age. Association of HCR with psoriasis seem to be due to linkage disequilibrium with CW*0602 (PubMed:11348465). HCR is unlikely to be directly involved in psoriasis development.,tissue specificity:Found in all tissues tested, abundantly expressed in heart, li
Gene Name
CCHCR1 C6orf18 HCR
Human protein sequence Database
Q8TD31
Mouse protein sequence database
Q8K2I2
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus.
Tissue expression
Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions.
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