Immunogen
Synthesized peptide derived from human GRHPR AA range: 151-201
Specificity
This antibody detects endogenous levels of GRHPR at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Glycolate + NADP(+) = glyoxylate + NADPH.,disease:Defects in GRHPR are the cause of hyperoxaluria primary type II (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.,function:Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Monomer.,tissue specificity:Ubiquitous. Most abundantly expressed in the liver.,
Gene Name
GRHPR GLXR MSTP035
Fields
>>Glycine, serine and threonine metabolism;>>Pyruvate metabolism;>>Glyoxylate and dicarboxylate metabolism;>>Metabolic pathways
Human protein sequence Database
Q9UBQ7
Mouse protein sequence database
Q91Z53
Rat protein sequence database
Cellular localization
cytoplasm,peroxisomal matrix,cytosol,extracellular exosome,
Tissue expression
Ubiquitous. Most abundantly expressed in the liver.
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