Immunogen
Synthesized peptide derived from human COTL1 AA range: 29-79
Specificity
This antibody detects endogenous levels of COTL1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008],
Function
function:Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization.,similarity:Belongs to the actin-binding proteins ADF family. Coactosin subfamily.,similarity:Contains 1 ADF-H domain.,subunit:Interacts with 5-lipoxygenase (5LO) in a calcium-independent manner.,tissue specificity:Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.,
Human protein sequence Database
Q14019
Mouse protein sequence database
Q9CQI6
Rat protein sequence database
B0BNA5
Cellular localization
Cytoplasm . Cytoplasm, cytoskeleton . Nucleus .
Tissue expression
Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
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