Immunogen
Synthesized peptide derived from human TRI66 AA range: 608-658
Specificity
This antibody detects endogenous levels of TRI66 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association.,similarity:Contains 1 bromo domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 2 B box-type zinc fingers.,subcellular location:Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm.,subunit:Can form homo- and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif.,
Gene Name
TRIM66 C11orf29 KIAA0298
Human protein sequence Database
O15016
Mouse protein sequence database
Q924W6
Rat protein sequence database
Cellular localization
Nucleus. Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. .
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