Immunogen
Synthesized peptide derived from human DAZL AA range: 202-252
Specificity
This antibody detects endogenous levels of DAZL at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
Function
disease:Defects in DAZL may be a cause of infertility due to severe oligozoospermia (AZ) and non obstructive azoospermia.,domain:The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.,function:RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts.,similarity:Belongs to the RRM DAZ family.,similarity:Contains 1 DAZ-like domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Predominantly cytoplasmic (By similarity). Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.,subunit:Homodimer and heterodimer (By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.,tissue specificity:Testis spe
Gene Name
DAZL DAZH DAZL1 DAZLA SPGYLA
Human protein sequence Database
Q92904
Mouse protein sequence database
Q64368
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. .
Tissue expression
Testis specific.
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