Immunogen
Synthesized peptide derived from human SNF8 AA range: 78-128
Specificity
This antibody detects endogenous levels of SNF8 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
Function
function:Component of the ESCRT-II complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL.,similarity:Belongs to the SNF8 family.,subunit:Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting required for transport complex II (ESCRT-II), composed of SNF8, VPS25 and VPS36. Interacts with TSG101, VPS25 and VPS36.,
Human protein sequence Database
Q96H20
Mouse protein sequence database
Q9CZ28
Rat protein sequence database
Q5RK19
Cellular localization
Cytoplasm. Endosome membrane. Nucleus . Late endosome membrane. Recruited to the endosome membrane to participate in vesicle formation.
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