Immunogen
Synthesized peptide derived from human DCK AA range: 62-112
Specificity
This antibody detects endogenous levels of DCK at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008],
Function
catalytic activity:NTP + deoxycytidine = NDP + dCMP.,function:Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DCK/DGK family.,subunit:Homodimer.,
Fields
>>Purine metabolism;>>Pyrimidine metabolism;>>Metabolic pathways;>>Nucleotide metabolism
Human protein sequence Database
P27707
Mouse protein sequence database
P43346
Rat protein sequence database
P48769
Cellular localization
Nucleus .
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