Immunogen
Synthesized peptide derived from human FHL5 AA range: 129-179
Specificity
This antibody detects endogenous levels of FHL5 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016],
Function
function:May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.,similarity:Contains 4 LIM zinc-binding domains.,subcellular location:Nuclei of round and elongated spermatids.,subunit:Interacts with CREM via the third LIM domain.,tissue specificity:Testis-specific (at protein level).,
Human protein sequence Database
Q5TD97
Mouse protein sequence database
Q9WTX7
Rat protein sequence database
Q6AXT1
Cellular localization
Nucleus . Nuclei of round and elongated spermatids.
Tissue expression
Testis-specific (at protein level).
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