Immunogen
Synthesized peptide derived from human CMPK2 AA range: 57-107
Specificity
This antibody detects endogenous levels of CMPK2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],
Function
catalytic activity:ATP + (d)CMP = ADP + (d)CDP.,function:May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.,similarity:Belongs to the thymidylate kinase family.,tissue specificity:Among all investigated tumors, leukemia cells show the most abundant expression.,
Fields
>>Pyrimidine metabolism;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors
Human protein sequence Database
Q5EBM0
Mouse protein sequence database
Q3U5Q7
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Among all investigated tumors, leukemia cells show the most abundant expression.
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