Immunogen
Synthesized peptide derived from human CHP3 AA range: 20-70
Specificity
This antibody detects endogenous levels of CHP3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
caution:It is uncertain whether Met-1 or Met-54 is the initiator.,cofactor:Binds calcium.,developmental stage:Strongly up-regulated in K562 cells treated by PMA to promote megakaryocytic differentiation, but not when treated by DMSO to promote granulocytic differentiation or by hemin to promote erythroid differentiation (at protein level).,function:Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with Sodium/hydrogen exchanger 1 (SLC9A1).,tissue specificity:Abundantly expressed in heart.,
Human protein sequence Database
Q96BS2
Mouse protein sequence database
Q9JKL5
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Membrane ; Lipid-anchor . Cell membrane . Cell projection, lamellipodium . Cell projection, ruffle membrane . Colocalizes with SLC9A1 at the plasma membrane. .
Tissue expression
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
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