Immunogen
Synthesized peptide derived from human SRGP2 AA range: 476-526
Specificity
This antibody detects endogenous levels of SRGP2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014],
Function
function:Putative GTPase-activating protein for Rho family small GTPases.,similarity:Contains 1 FCH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,subunit:Probably interacts with ROBO1.,tissue specificity:Expression at low levels in placenta, kidney, and ovary, and little or no expression in all other tissues tested.,
Gene Name
SRGAP2 ARHGAP34 FNBP2 KIAA0456 SRGAP2A
Human protein sequence Database
O75044
Mouse protein sequence database
Q91Z67
Rat protein sequence database
D4A208
Cellular localization
Cell membrane . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic density . Cell junction, synapse, postsynaptic cell membrane . Cell projection, lamellipodium . Cytoplasmic vesicle, phagosome . Nucleus . Cytoplasm, cytosol . Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (By similarity). .
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