Immunogen
Synthesized peptide derived from human BHE22 AA range: 243-293
Specificity
This antibody detects endogenous levels of BHE22 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. [provided by RefSeq, Oct 2016],
Function
function:Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,tissue specificity:Brain-specific, with the highest expression in the cerebellum.,
Gene Name
BHLHE22 BHLHB5 TNRC20
Human protein sequence Database
Q8NFJ8
Mouse protein sequence database
Q8C6A8
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Brain-specific, with the highest expression in the cerebellum.
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