Immunogen
Synthesized peptide derived from human TBCD7 AA range: 85-135
Specificity
This antibody detects endogenous levels of TBCD7 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the TBC-domain containing protein family. The encoded protein functions as a subunit of the tuberous sclerosis TSC1-TSC2 complex which plays a role in the regulation of cellular growth and differentiation. Mutations in this gene have been associated with autosomal recessive megalencephaly. Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between this locus and downstream LOC100130357. [provided by RefSeq, Jan 2016],
Function
function:May act as a GTPase-activating protein for Rab family protein(s) .,similarity:Contains 1 Rab-GAP TBC domain.,
Gene Name
TBC1D7 HSPC239 TBC7
Fields
>>mTOR signaling pathway
Human protein sequence Database
Q9P0N9
Mouse protein sequence database
Q9D0K0
Rat protein sequence database
Cellular localization
Cytoplasmic vesicle . Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.
Tissue expression
Highly expressed in heart, and slightly in kidney, liver and placenta.
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