Immunogen
Synthesized peptide derived from human PHLP2 AA range: 381-431
Specificity
This antibody detects endogenous levels of PHLP2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Gene Name
PHLPP2 KIAA0931 PHLPPL
Fields
>>PI3K-Akt signaling pathway
Human protein sequence Database
Q6ZVD8
Mouse protein sequence database
Q8BXA7
Rat protein sequence database
Cellular localization
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
Tissue expression
In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level).