Immunogen
Synthesized peptide derived from human FIGLA AA range: 103-153
Specificity
This antibody detects endogenous levels of FIGLA at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009],
Function
developmental stage:Expressed in ovarian follicles (from the primordial through to the secondary stage), in mature oocytes, and less frequently in preimplantation embryos.,disease:Defects in FIGLA are the cause of premature ovarian failure type 6 (POF6) [MIM:612310]. POF is a group of heterogeneous disorders in which amenorrhea associated with elevated levels of serum gonadotropins occurs long before the age of 40 years.,function:Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it ma
Human protein sequence Database
Q6QHK4
Mouse protein sequence database
O55208
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid-gestation, rising some 40-fold by the time of primordial follicle formation.
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