Immunogen
Synthesized peptide derived from human EXOS1 AA range: 93-143
Specificity
This antibody detects endogenous levels of EXOS1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Function
domain:The N- and C-terminal regions of the protein are required for interaction with RRP46.,function:Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity.,similarity:Contains 1 S1 motif domain.,subunit:Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: EXOSC1/CSL4, EXOSC2/RRP4, EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3, EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, and EXOSC10/Scl-100 (only in the nuclear complex). Interacts directly with EXOSC5, EXOSC6, EXOSC7 and EXOSC8. Also associated with the GTPase Ran.,
Gene Name
EXOSC1 CSL4 CGI-108
Human protein sequence Database
Q9Y3B2
Mouse protein sequence database
Q9DAA6
Rat protein sequence database
Cellular localization
Nucleus, nucleolus . Nucleus . Cytoplasm .
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