Immunogen
Synthesized peptide derived from human ZFY27 AA range: 351-401
Specificity
This antibody detects endogenous levels of ZFY27 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010],
Function
disease:Defects in ZFYVE27 are the cause of spastic paraplegia autosomal dominant type 33 (SPG33) [MIM:610244]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.,similarity:Contains 1 FYVE-type zinc finger.,subcellular location:Punctate vesicles.,subunit:Interacts with SPAST/spastin.,
Human protein sequence Database
Q5T4F4
Mouse protein sequence database
Q3TXX3
Rat protein sequence database
Q6P7B7
Cellular localization
Recycling endosome membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, growth cone membrane ; Multi-pass membrane protein . Localizes at both dendrites and axons (By similarity). Localizes to endoplasmic reticulum tubular network. .
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