Immunogen
Synthesized peptide derived from human SG196 AA range: 178-228
Specificity
This antibody detects endogenous levels of SG196 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013],
Function
domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.,similarity:Contains 1 protein kinase domain.,
Fields
>>Mannose type O-glycan biosynthesis;>>Metabolic pathways
Human protein sequence Database
Q9H5K3
Mouse protein sequence database
Q3TUA9
Rat protein sequence database
Q4V8A9
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
Tissue expression
Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues.
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