Immunogen
Synthesized peptide derived from human METK2 AA range: 294-344
Specificity
This antibody detects endogenous levels of METK2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011],
Function
catalytic activity:ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.,cofactor:Binds 1 potassium ion per subunit.,cofactor:Binds 2 divalent ions per subunit. Magnesium or cobalt.,function:Catalyzes the formation of S-adenosylmethionine from methionine and ATP.,pathway:Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.,PTM:The alpha' subunit is a post-translationally modified version of MAT2A.,similarity:Belongs to the AdoMet synthetase family.,subunit:Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta subunit (MAT2B).,
Gene Name
MAT2A AMS2 MATA2
Fields
>>Cysteine and methionine metabolism;>>Metabolic pathways;>>Biosynthesis of amino acids;>>Biosynthesis of cofactors
Human protein sequence Database
P31153
Mouse protein sequence database
Q3THS6
Rat protein sequence database
P18298
Cellular localization
cytosol,methionine adenosyltransferase complex,
Tissue expression
Detected in kidney.
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