Immunogen
Synthesized peptide derived from human SAC2 AA range: 1006-1056
Specificity
This antibody detects endogenous levels of SAC2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],
Function
function:Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.,miscellaneous:Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.,similarity:Contains 1 SAC domain.,tissue specificity:Ubiquitous.,
Gene Name
INPP5F KIAA0966 SAC2 MSTP007 MSTP047
Fields
>>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system
Human protein sequence Database
Q9Y2H2
Mouse protein sequence database
Q8CDA1
Rat protein sequence database
Cellular localization
Membrane, clathrin-coated pit . Early endosome . Recycling endosome . Also found on macropinosomes. .
Tissue expression
Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).
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