Immunogen
Synthesized peptide derived from human ARL8B AA range: 9-59
Specificity
This antibody detects endogenous levels of ARL8B at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:May play a role in lysosomes motility (PubMed:16537643). May play a role in chromosomes segregation (PubMed:15331635).,similarity:Belongs to the small GTPase superfamily. Arf family.,subcellular location:According to PubMed:15331635 it localizes with microtubules at the spindle mid-zone during mitosis.,subunit:Interacts with tubulin.,tissue specificity:Ubiquitously expressed.,
Gene Name
ARL8B ARL10C GIE1
Fields
>>Salmonella infection
Human protein sequence Database
Q9NVJ2
Mouse protein sequence database
Q9CQW2
Rat protein sequence database
Q66HA6
Cellular localization
Late endosome membrane . Lysosome membrane . Cytoplasm, cytoskeleton, spindle . Cell projection, axon . Cell junction, synapse . Cytolytic granule membrane . GTP-bound form resides on lysosomal membranes, whereas GDP-bound form is likely associated with microtubular structures (PubMed:16650381). Localizes with microtubules at the spindle mid-zone during mitosis. In dendritic cells, localizes to MHC II+ compartments (By similarity). .
Tissue expression
Ubiquitously expressed.
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