Immunogen
Synthesized peptide derived from human TPC1 AA range: 104-154
Specificity
This antibody detects endogenous levels of TPC1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008],
Function
domain:Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.,function:May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane.,similarity:Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.,subunit:Dimer .,tissue specificity:Highest expression found in the heart and kidney, and lowest expression found in the spleen.,
Gene Name
TPCN1 KIAA1169 TPC1
Fields
>>Calcium signaling pathway
Human protein sequence Database
Q9ULQ1
Mouse protein sequence database
Q9EQJ0
Rat protein sequence database
Q9WTN5
Cellular localization
Lysosome membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein .
Tissue expression
Highest expression found in the heart and kidney, and lowest expression found in the spleen.
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